Nowa bezrozpuszczalnikowa metoda enkapsulacji leków w materiałach typu MOF

Scientists from our Faculty have developed new solvent-less one-pot method of drug encapsulation in MOF-class materials (Metal-Organic Framework). Method is based on mechanochemical process which makes manufacturing of MOF-encapsulated drugs faster as well as cheaper, yielding drug@MOF composite. The advantage of such drug transport form over conventional forms is possibility of performing targeted therapy as well longer drug release (in weeks). Method has been developed by team of Prof. Janusz Lewiński: Daniel Prochowicz, PhD, Eng. and Jan Nawrocki, MSc, Eng. along with their colleagues from Institute of Physical Chemistry, Polish Academy of Science. The team have published paper in European Journal of Inorganic Chemistry in which they presented results of using Ibuprofen@MOF (obtained with new method) as a proof of concept which was released over the course of 14 days in the conditions simulating human organism. Article is highlighted an on the cover of an issue.

Link to the issue cover
Link to the article