Zapraszamy na seminarium wydziałowe pt. 

X-ray Absorption Spectroscopy in Organic Chemistry

Temat przedstawi Dr. Yuta Uetake (The University of Osaka), lauteat nagrody Green Catalysis Lectureship Award.

 
Termin

9.09.2025 (wtorek), godz. 14:15

   
Miejsce

Gmach Technologii Chemicznej
Audytorium im. I. Mościckiego
 
 
Abstract

X-ray absorption spectroscopy (XAS) is a powerful technique for elucidating the electronic states and local structures of target atoms. A key advantage of XAS lies in its applicability across diverse environments, including organic solvents, which makes it highly attractive for probing organic compounds and reaction intermediates. Despite this potential, the use of solution-state XAS in organic chemistry has remained limited.

Our group has explored XAS as a tool to deepen the mechanistic understanding of organic reactions. To this end, we have developed both in situ and ex situ solution cells, as well as reaction apparatuses compatible with organic solvents, thereby enabling solution-state XAS experiments under realistic conditions.^[1–3] In this seminar, I will introduce our recent developments and applications of solution-state XAS to organic chemistry. In particular, I will focus on the characterization of reaction intermediates in a Lewis acid–mediated Suzuki–Miyaura cross-coupling reaction.^[1] Through solution-state XAS, we identified a stable triflate-bridged Pd/Zn binuclear resting-state complex. Complementary theoretical calculations revealed that highly reactive cationic Pd species are gradually released from this complex, thus achieving a balance between reactivity and thermal stability. Furthermore, I will discuss the structural analysis of densely fluorinated cubanes—specifically hexafluorodihalocubanes—that exhibit exceptionally short carbon–halogen bonds.^[3] By combining solution-state XAS with single-crystal X-ray diffraction, we were able to disentangle solvent effects and packing forces that influence carbon–halogen bond lengths, highlighting the unique insights afforded by solution-state XAS.

  
References

[1]   Niwa, T.; Uetake, Y.; Isoda, M.; Takimoto, T.; Nakaoka, M.; Hashizume, D.; Sakurai, H.; Hosoya, T. Nat. Catal. 2021, 4, 1080–1088.

[2]   Yamauchi, Y.; Ogoshi, S.; Uetake, Y.; Hoshimoto. Y. Chem. Lett. 2025, 53, upae042.

[3]   Sugiyama, M.; Uetake, Y.; Miyagi, N.; Yoshida, M.; Nozaki, K.; Okazoe, T.; Akiyama, M. J. Am. Chem. Soc. 2024, 146, 30686–30697.

 
O prelegencie

Dr. Uetake is an assistant professor specializing in homogeneous catalysis, particularly in the analysis of reaction intermediates in solution and the electronic states of transition-metal-complexes using X-ray absorption spectroscopy.

• Nat. Catal. 2021, 4, 1080: https://www.nature.com/articles/s41929-021-00719-6;
• JACS 2024, 146, 30686: https://pubs.acs.org/doi/10.1021/jacs.4c12732;
• JACS 2025, 147, 8326: https://pubs.acs.org/doi/10.1021/jacs.4c15892.

Professional Experiences

• 2017– Assistant Professor
  Department of Applied Chemistry, The University of Osaka

Other Professional Experiences

• 2020–2025 Visiting Researcher, RIKEN BDR
• 2023–2024 Special Fellow, Nanocarbon Devise Research Center, AIST

Professional Activity

• Member, The Chemical Society of Japan
• Member, Catalyst Society of Japan
• Member, The Society of Synthetic Organic Chemistry, Japan
• Member, The Japanese XAFS Society

  
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